Several studies that have examined interactions between single variants in different genes have shown mixed evidence of two-way interactions in T2DM and T2DM-related traits like obesity and insulin resistance.
However, the few association studies investigating glutamate genes have yielded mixed results, and all of the above-mentioned studies were conducted on Caucasian populations.
Studies investigating sites within candidate genes have shown mixed results, although together, findings suggest associations between DNA methylation and alcohol use or alcohol use disorders in human samples, although the relationships appear complex [ 39].
For Julian, genes have proved a mixed blessing.
Recently, the mosaic or mixed DNA methylation states of PCDHA@ genes have been characterized in mouse neural cells and in vivo 31.
Previous work using correlation-based methods to identify clusters of coordinately expressed genes has had mixed success [ 4, 10, 16, 47].
However, apart from SMRT (NCOR2) and NR4A1 (both on 12q24 and showing increased gain in pure DCIS and increased loss in mixed DCIS), none of the genes has been associated with breast cancer in other studies.
Mixed marriages have produced mixed-race children.
Other than fibrinogen-related genes (which had a mixed pattern), coagulation-related genes with higher expression in infected frogs were generally inhibitory (e.g. 287154) so the net effect of deactivation of coagulation genes appears consistent.
The subsets of expressed genes with at least two-fold changes were used for their potential interactions using the STRING 9.05 precomputed database [ 40], and the results indicated that acetate upregulated genes in mixed sugar fermentation had better interactions than those of the downregulated ones (Additional file 2: Figure S6).
