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While these agents have been abundantly safe, there has been mixed efficacy seen and somewhat more modest results than expected when compared to preclinical models.
Several characteristics of the clinical phenotype and therapeutic responses we report are consistent with those previously described for LQT-3 cases in infants, including both pronounced QT prolongation (594 ms to 740 ms[11] [26], [26]) and mixed efficacy in the controlling QT prolongation and resulting arrhythmias with Na+ channel blockers[9], [11], [24], [26].
Supportive treatments exist, but are of mixed efficacy and do not restore mobility.
Plasma exchange and high cutoff dialysis have been examined with mixed efficacy.
Given this mixed efficacy against different bacteria, each gallium formulation needs to be thoroughly tested in vitro and in vivo against each pathogen.
Due to the mixed efficacy reported in case reports of rfVIIa, we use the aPCC (Feiba) prior to rfVIIa in refractory bleeding associated with dabigatran [ 21, 22].
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We review seven key efficacy/effectiveness design decisions in this mixed "efficacy-effectiveness" trial.
Non-steroidal anti-inflammatory drugs (NSAIDs) require further investigation given mixed results regarding efficacy.
Systematic reviews of lumbar fusion outcomes in purely workers' compensation (WC) patient populations have indicated mixed results for efficacy.
So-called "distracted driving" laws have a mixed history of efficacy.
To date, trials of DAART have yielded mixed findings regarding efficacy [ 2, 3].
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