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Anti-Xa activity time-courses were analyzed using a non linear mixed effects approach with Monolix version 2016R.
Parameters were estimated using a linear mixed effects approach.
A mixed effects approach is used in which some parameters have both fixed and random effects.
Individual pharmacokinetic parameters were calculated according to a nonlinear mixed effects approach using NonMem program (Version VI, level I).
We used a multi-level mixed effects approach to model and then synthesise wages for working individuals by SOC units (the finest detailed grouping within the SOC).
The presented study uses a non-linear mixed effects approach with a higher statistical power to detect and quantify any interaction.
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Currently, PK/PD modeling of clinical or nonclinical data is routinely modeled using population (mixed effects) approaches rather than individual or pooled datasets.
A number of model forms for diameter height relationship [43-48] [43-48]sted using non-linear mixed effect approach.
A number of model forms for diameter height relationship [ 43- 48] were tested using non-linear mixed effect approach.
This constitutes a mixed-effect approach which allows for inferences from these results to be made about the larger population.
Therefore, we will account for this by generalising the conventional linear (fixed effects) regression approach to a mixed effects modelling approach, where patients are naturally grouped by recruiting centres (random effects).
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