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The analysis was performed by non-linear mixed effect modelling using the NONMEM® computer program.
The LinExp model was computed by population non-linear mixed effect modelling using function nlme [ 19].
Data collected in the two clinical studies were pooled and analyzed simultaneously using non-linear mixed effect modelling.
Since usually only a limited number of observations can be obtained in paediatric subjects, the population approach using non-linear mixed effect modelling to obtain PK and PD parameters is the preferred approach [ 37].
A retrospective analysis was subsequently conducted using mixed effect modelling to investigate the temporal pattern of blood Co levels in the patients and survival analysis to investigate the potential role of case demographics and blood Co levels as risk factors for subsequent failure secondary to ARMD.
Pharmacokinetic calculations for cyclophosphamide, 4-hydroxycyclophosphamide and phosphoramide mustard were performed based on two population pharmacokinetic models previously developed in our institute (Huitema et al, 2001; De Jonge et al, 2004) using the nonlinear mixed effect modelling program NONMEM (double precision, version V 1.1) (Beal and Sheiner, 1998).
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Mixed effect modeling of hospitalized diarrheal admissions.
Pharmacokinetic parameters were estimated by non-linear mixed effect modeling.
Through mixed effects modelling, the correlation structure of the data can be explicitly examined by researchers.
A Berkey-Reed first order model (Berkey, 1982) was fitted using mixed effects modelling.
Mixed effects modeling is a valuable tool in mass spectrometry-based proteomics research.
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