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A limitation of our study is that the study sample of peripheral blood mononuclear cells contained a heterogeneous mix of cell types that may have obscured any phenotypic changes in IRGM1 expression.
The tumour microenvironment is a heterogeneous mix of cell types that includes stromal constituents.
For example, the lesion samples contain a mix of cell types obtained at a fixed time point.
Additionally, differences between the mix of cell types in a tumor and whole ovary normal samples may cause certain disparities.
However, these leukocytes are made up of a diverse mix of cell types of different ages, which could result in a range of telomere lengths (63, 64).
The prostate represents a complex mix of cell types and there is a need to analyze distinct cell populations to better understand their potential interactions.
Similar(48)
In our application to the problem of discovering new cell markers, we sought to determine whether this simple assumption could yield specific genes for an uncharacterized target cell-type mixed with an arbitrary number of cell types (characterized or not).
This model maintains the cell cell contact of the complex mix of different cell types whose interaction contributes to the pro-inflammatory environment in the RA joint.
This model more closely reflects the in vivo joint environment, as it maintains tissue architecture and cell-cell contact of the complex mix of different cell types whose interaction contributes to the pro-inflammatory environment in the RA joint.
Moreover, some of these cultures lack a complete mix of the cell types that reside in the CNS, which means the cross-talk among various CNS cell types may be lacking, and thus represent an oversimplified system.
Another limitation of our study is that the majority of the samples was obtained by surgical dissection of tumor tissue and therefore represent a mix of different cell types.
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