Hernandez, G. et al. MitoTimer: a novel tool for monitoring mitochondrial turnover.
Terman, A., Dalen, H., Eaton, J. W., Neuzil, J. & Brunk, U. T. Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover.
Palikaras, K., Daskalaki, I., Markaki, M. & Tavernarakis, N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover.
Currently, there is limited understanding about hormonal regulation of mitochondrial turnover.
The authors claimed that the activation of mitophagy led to higher mitochondrial turnover during early chondrogenesis.
The CMA markers, LAMP-2A and Hsc70, and mitochondrial turnover markers, Drp1, PINK1 and PGC1α also were decreased.
Taken together, our studies showed similar declines in macroautophagy but distinct effects on CMA, mitochondrial turnover, and metabolic dysfunction in muscle vs. heart during aging.
Mitochondria damage-induced autophagy or "mitophagy" is one of the major degradation pathways in mitochondrial turnover and homeostasis (Kim et al., 2007).
These findings demonstrate a novel ROS-AMPK-ULK1 mechanism that couples T3-induced mitochondrial turnover with activity, wherein mitophagy is necessary not only for removing damaged mitochondria but also for sustaining efficient OXPHOS.
In total, the results indicate that inhibition of autophagy by IGF-I decreases cell viability through interference with mitochondrial turnover.
The regulation of mitochondrial turnover including clearance of dysfunctional mitochondria is essential for cellular homeostasis and survival [37].
