Sentence examples for mitochondrial transitions from inspiring English sources

Not surprisingly, transition:transversion saturation plots revealed that rates of mitochondrial transitions far exceeded those of all other partitions.

As regards the mitochondrial pathway, the most critical events during apoptosis are the release of cytochrome c from mitochondria into cytosol, after development of the mitochondrial transition pore.

The opening of mitochondrial transition pore complex was determined by mitochondrial swelling and shrinking assay.

The activation of caspases 9 and 3 is likely mediated by the mitochondrial transition pore.

Metformin also inhibits mitochondrial transition pore and mitochondria-linked cell death [ 26].

Finally, CoQ10 plays a role in the control of mitochondrial transition pore opening, which is involved in apoptosis.

The calcein/Co2+-quenching technique was used to elucidate the subtle phenomena associated with mitochondrial permeability transition leading to programed cell death using the Image-iT LIVE Mitochondrial Transition Pore Assay Kit (Life Technologies), as previously described.

Furthermore, we show that this is associated with distinct mitochondrial phenotypes, including altered intracellular [Ca2+] levels, dysfunctional mitochondrial transition-pore opening, hyperpolarization and superoxide leakage from resting mitochondria.

ROS are able to open mitochondrial transition pores leading to an interruption of mitochondrial potential and release of apoptogenic factors (Kroemer et al, 1997).

Experiments using well-characterized apoptosis inhibitors place protein carbonylation downstream of the mitochondrial transition pore opening and upstream of caspase activation.

Opening of the mitochondrial transition pore (MTP) is involved in the activation of caspase 9, and CsA inhibits opening of the MTP (36).