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Recent studies from our laboratory and others have demonstrated that macrophages also depend on mitochondrial support for ROS generation during responses to pathogens30,31,41.
21 Recent studies showed that reduced doses of 22q11 genes could modify the initial forebrain patterning, subsequent cortical neurogenesis and migration, and the mitochondrial support of activity-dependent synapse formation and elimination in the early postnatal brain.
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This revealed the surprising observation that identical proteins are deregulated by HA and Aβ, but not rat amylin, and a quarter of these were mitochondrial, supporting the notion that mitochondrial dysfunction is a common target in these two amyloidoses.
Using Western blotting analysis, we detected also a decrease in the levels of total (Fig 2G) and mitochondrial (Supporting Information Fig S5) Cytc in morphant embryos, similarly to what demonstrated in the yeast.
Finally, while phylogenetic analyses of the mitochondrial sequences support a basal deuterostome placement, support for this decreases with the use of more sophisticated models of sequence evolution.
Several related phylogenetic analyses based on mitochondrial data support this basal dichotomy [2], [16], [18], [34].
Contrasting these results, analyses of mitochondrial sequences support an annelid affinity for myzostomids.
Phylogenies based on chloroplast and mitochondrial genomes support the latter view.
The observations from both studies regarding gene expression and mitochondrial dysfunction support findings generated in other models.
The mitochondrial data support the units found using microsatellite markers, indicating that distinct genetic management units could be implemented.
Conversely, mitochondrial sequences support a basal deuterostome position [ 16], but when amino acids with a different genetic code are excluded, Xenoturbella was recovered as basal ambulacrarian [ 7].
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