Sentence examples for mitochondrial replication system from inspiring English sources
This study thus proposes that the mitochondrial replication system utilises distinct proteins, DNA ligase III and RNase H1, for Okazaki fragment maturation.
The DNA2/FEN1 pathway might therefore be functionally dispensable and may be a minor pathway in the human mitochondrial replication system.
Our findings thus suggest that DNA ligase III and RNase H1 substitute for DNA ligase I and RNase H2 respectively in the human mitochondrial replication system.
We evaluate our findings in the context of functions at the mitochondrial replication fork, and discuss them in comparison with other DNA replication systems.
Intergenic spacers are usually limited in number and size, and their occurrence is believed to be the result of errors of the mtDNA replication system (i.e. duplication of parts of the mitochondrial genomes, with redundant copies becoming pseudogenes and disappearing).
High mutational rates in mtDNA have been associated with an inaccurate DNA repair system (Bogenhagen 1999 ), the absence of histone-like protein, and the peculiar mitochondrial replication model, characterized by single-strand intermediates, which was found to be a convincing explanation for strand mutational bias (Reyes et al. 1998 ).
Indeed, yeast mitochondrial replication origins activate replication of plasmids [13], [16].
Oocyte mitochondria must support early embryonic development until the resumption of mitochondrial replication.
The D-loop regulates mitochondrial replication and transcription in accordance with the energy demands, while the mitochondrial rRNAs and tRNAs ensure fulfillment of this task.
A novel origin of replication was found close to 16189 in the mitochondrial CR, suggesting a model in which the 16189 variant could reduce mitochondrial replication and thereby mtDNA content of the cell through altered binding affinity of mtSSB [6].
The mitochondrial replication machinery is encoded by nuclear genes, the products of which translocate to the mitochondrion.
