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Mitochondrial organization, dynamics, and interactions with other intracellular structures and organelles are crucial for proper cell physiology.
Together, these recent studies demonstrate the importance of mitochondrial organization in generating cellular architecture and vice versa.
In this review we will discuss recent work on the significance of mitochondrial organization in regulating the size and distribution of mitochondrial DNA nucleoids and emphasize the importance of a new role for actin in regulating mitochondrial dynamics.
as well as decreased "mitochondrial organization" genes in addition to others (Fig. 6A C).
Apart from the severe developmental disturbance, the observed alterations in mitochondrial organization are interesting and might indicate a functional defect.
This finding might explain the property of PB1-F2 to disrupt the reticulotubular mitochondrial organization and to dissipate the inner membrane potential [4], [10].
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There is a direct coupling between mitochondrial organization-movement-activity and synaptic activity [ 73].
These two different genome organizations have a clearly defined phylogenetic distribution within the Homoscleromorpha: all spiculate homoscleromorphs have Plakinastrella sp.-like mitochondrial genome organization, while all aspiculate homoscleromorphs have O. carmela-like mitochondrial genome organization.
The mitochondrial genome organization shows great evolutionary variability, even in closely related organisms.
Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization and interactions.
Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization.
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