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These results demonstrate clearly that LETM1 causes mitochondrial morphologic changes.
Delivery of Tat to murine CNS in vivo also leads to long-lasting pathologic ER dilatation and mitochondrial morphologic abnormalities.
To detect the mitochondrial morphologic change after overexpressing LETM1, analysis by confocal laser scanning microscopy (CLSM) and transition electron microscopy (TEM) was performed.
Many apoptotic stimuli can elicit mitochondrial morphologic changes during the early apoptotic stage, resulting in small, round and more numerous organelles [36] [38].
The mitochondrial-targeted reactive oxygen species scavenger MitoQ positioned these species as second messengers between mitochondrial morphologic alterations and autophagy.
More importantly, GSK2578215A activates Drp1 translocation in a time-dependent manner, coinciding with the observed mitochondrial morphologic changes.
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Since mitochondrial dysfunction precedes morphologic alterations, it would permit an early diagnosis of mitochondria-associated rhabdomyolyses in horses.
Although morphologic clues of mitochondrial dysfunction in these equine diseases have accumulated, a functional confirmation is still pending.
Paraspinal muscle biopsy showed morphologic evidence of a mitochondrial myopathy.
The species were identified on the basis of morphologic characters and the mitochondrial cytochrome b (cytb) gene sequence.
The original suggestion that A. darlingi is a species complex [ 17, 23] was refuted by Manguin and others [ 9] with a genetic and morphologic survey, although recent mitochondrial and nuclear range-wide studies provide support for the initial hypothesis [ 10, 28].
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