Sentence examples for mitochondrial led from inspiring English sources

The major finding of this report is that accumulation of mitochondrial led to IGF-1 resistance by tilting the delicate balance of regulatory kinases and phosphatases towards enhanced activities of PTP1B and PTEN, key phosphatases of the IGF-1 signalling pathway.

Finally, Anandatheerthavarada and Devi [ 51] showed that APP contains a mitochondrial targeting sequence and that an accumulation of APP in mitochondrial membranes leads to mitochondrial dysfunction in Tg2576 neurons.

Mitochondrial inhibition led to dramatic reductions in OCR during 2DG treatment, demonstrating mitochondrial involvement during glucose-independent respiratory burst (Fig. 2b, Supplemental Fig. 3b).

In this study we show that preventing mitochondrial fragmentation leads to mitochondrial oxidative damage and mtDNA loss and that expressing a H2O2 scavenger at the mitochondria in D1 cells prevents the loss of mtDNA.

It was suggested that NAPQI binding to mitochondrial proteins leads to mitochondrial oxidative stress.

Together, a fall in ATP concentration and oxidative stress exerted on mitochondrial metabolites lead to mitochondrial permeability transition pore opening with eventual organelle swelling and cytochrome c release.

We next sought to determine if the observed mitochondrial fragmentation led to increased susceptibility to cell death by intrinsic stimuli that engage the mitochondrial pathway.

Hyperoxia can exacerbate cellular oxidative stress injury and mitochondrial dysfunction to key mitochondrial enzymes or mitochondrial lipids, leads to cerebral O2-related vasoconstriction with a decreased cerebral blood flow (CBF) and cerebral energy metabolism impairment.

Mitochondrial damage led to the depolarization of the mitochondria and caused the decrease of the membrane potential.

Recent studies show that targeted mitochondrial damage led to up-regulation of autophagy genes LC3B, ATG5, and ATG12 in human endothelial cells (Mai et al., 2012).

These results suggest that p43-induced mitochondrial alterations led to a general reduction in MyHC expression, particularly MyHC-IIx.