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mitochondrial intermembrane space.
CuZn-SOD (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein (Li et al., 2013).
Endonucleases from the mitochondrial intermembrane space and lysosomes are responsible for nuclear DNA fragmentation.
Effectively, the release of cytochrome c (Cyt. c) from the mitochondrial intermembrane space into the cytosol follows.
ActB: cytosol; Mortalin: mitochondrial matrix; TOM40: mitochondrial outer membrane; TIM23: mitochondrial inner membrane; DDP2: mitochondrial intermembrane space.
Additionally, mitofilin is coupled to the outer membrane and promotes protein import via the mitochondrial intermembrane space assembly pathway.
Aup1 was a member of the phosphatase2c superfamily and localized to the mitochondrial intermembrane space; it facilitated mitophagy in stationary phase cells (Tal et al., 2007).
The O2 − generated from complex III is released into the mitochondrial intermembrane space and is converted to H2O2 by copper/zinc superoxide dismutase (Cu/ZnSOD).
Two mitochondrial CK (mtCK) isoforms have also been characterized, namely muscle-specific sarcomeric (smtCK) and ubiquitous mtCK, both of which localize to the mitochondrial intermembrane space [2].
The mitochondrial import and assembly (MIA) pathway plays a vitally important role in import and oxidative folding of the mitochondrial intermembrane space (IMS) proteins.
Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways.
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