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Mitochondrial inheritance and cancer.
"It is possible that there are things we do not understand about mitochondrial inheritance and mutation patterns," Pääbo says.
However, with variant data alone, both mitochondrial inheritance and somatic mutation terms achieve AUCs above 0.9.
Because plastids are paternally inherited in Pinaceae (Neale and Sederoff, 1989), plastids potentially track pine pollen flow in contrast to maternal mitochondrial inheritance and biparental nuclear inheritance.
The authors observed an excellent AUROC score for mitochondrial inheritance, and speculate that the reason is that the mitochondrial genome is well studied.
Mitochondrial inheritance and dynamics in yeast are maintained by distinct mechanisms: the fission and fusion of mitochondria, the mitochondrial segregation from mother to daughter, and the maintenance of mitochondria [ 71].
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This would have ensured sustained close contacts between host cytoplasm and proto-mitochondria, increasing the probability of vertical proto-mitochondrial inheritance, and helping to exclude parasitic microbes.
Given the peculiar features of mitochondrial inheritance, genetics and physiology, how transmission of viable mtDNA through generations is achieved is object of debate.
Objective: To determine the patterns of mitochondrial inheritance in embryos, fetuses, and infants after ooplasmic transplantation using the technique of mitochondrial DNA (mtDNA) fingerprinting.
Interestingly, toward the end of the lag phase directly preceding entry into exponential growth phase, mitochondria become more reducing and mitochondrial inheritance into the bud is restored.
Thanks to its features, DUI provides a unique and evolutionary stable system to study mitochondrial inheritance, heteroplasmy, mitonuclear coevolution, genomic conflicts, and many basic aspects of mitochondrial biology [ 2, 22, 30].
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