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Five reliable mitochondrial haplogroups have previously been described in domestic goats [13] [15], [18].
Monoallelic markers, Y chromosomal and mitochondrial haplogroups, have proven to be very useful for understanding the patrilineal and matrilineal origins of Jewish Diaspora groups.
Mitochondrial haplogroups have been associated with diverse multifactorial diseases, such as Alzheimer's disease [ 17], hypertrophic cardiomyopathy [ 18], retinal diseases [ 19] or age-related macular degeneration [ 20].
Mitochondrial haplogroups have been associated with the expression of mitochondrial-related diseases (metabolic syndrome, type 2 diabetes, neurological disorders, infertility, and Parkinson's disease) and with various individual characteristics (aging and endurance training capacity) [ 3, 10– 14], but, to our knowledge, their role has not yet been investigated in morbid obese Caucasian subjects.
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The HV mitochondrial haplogroup has a west Eurasian origin and is found throughout West Asia and Southeastern Europe, including Iran, Anatolia (present-day Turkey), the Caucasus Mountains of southern Russia and the Republic of Georgia [ 16].
Previously, some European mitochondrial DNA haplogroups have been correlated with clinical conditions caused by mitochondrial DNA mutations (Hudson et al., 2007).
Mitochondrial DNA haplogroups have been associated with metabolic disorders in various populations [ 3, 22, 23], although not yet in morbid obese Caucasians from southern Italy.
Mitochondrial DNA (mtDNA) haplogroups have been associated with the expression of mitochondrial-related diseases and with metabolic alterations, but their role has not yet been investigated in morbid obese Caucasian subjects.
The phylogeny of the indigenous Indian-specific mitochondrial DNA (mtDNA) haplogroups have been determined and refined in previous reports.
However, mitochondrial DNA (mtDNA) haplogroups have been widely reported as factors for degenerative pathologies and neurodegenerative conditions, including Parkinson disease (PD), Alzheimer disease (AD), Huntington disease, and motor neuron disease.
For example, a breed composed of two mitochondrial haplogroups would have a bimodal mismatch distribution due to within- and between-breeds pairwise differences, and should not be interpreted in term of demographic history of the breed.
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