Sentence examples for mitochondrial genome copy from inspiring English sources
Previous work has suggested that the eosinophilic variant of chRCC has more mitochondrial genome copy numbers than normal kidney and that such tumors share a number of molecular characteristics with oncocytomas [15].
Furthermore, reduced ATP could lead to mitochondrial damage and increased mitochondrial genome copy number or mitochondrial mass.
The increase in mitochondrial genome copy number (Figure 5, C and D) appears to indicate the former but this can be partially accounted for by increased mitochondrial replication suggesting the overall response is a combination of both increased replication and genome amplification (Figure 4F).
These findings indicate the involvement of mitochondrial genome copy number and sequence in an organism's response to stress.
In addition, if the disease process invokes mitochondrial depletion, this could increase nuclear pseudogene signal in reactions as a result of reduced mitochondrial genome copy number [ 32].
To assess the influence of msh1 recombination on mitochondrial genome copy number, we compared relative copy number at 11 sites within the mitochondrial genome of the wild type (Col-0) and the msh1 mutant.
Mitochondrial genomic analysis in a single cell revealed that the mitochondrial genome copy-number/cell was significantly reduced in high-grade tumors (Gleason grade 8 and 9) as compared with that in low-grade tumors (Gleason grade 6 and 7) (P<0.01).
Each cell contains several mitochondrial genome copies and mitochondrial DNA recombination is a widespread process occurring in plants, fungi, protists, and invertebrates.
The sequencing coverage on the mitochondrial genome indicates that there were of order M = 100 mitochondrial genome copies present per cancer cell.
Deep genome coverage was observed for the mtDNA, and compared with the D. ananassae nuclear genome, the D. ananassae strains with the wAnaITG genomes had more mitochondrial genome copies than D. ananassae strains with the wAnaINF genomes (table 1).
We also used primers internal to the deleted regions in PCR reactions to probe for the presence of intact mitochondrial genome copies wherever possible in all cases analyzed, wild-type copies were detected.
