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Westermann, B. Bioenergetic role of mitochondrial fusion and fission.
Mitochondrial fusion is essential for maintenance of mitochondrial function.
Frezza, C. et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.
Chen, H. et al. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits cristae remodeling, protects from mitochondrial dysfunction.
Anand, R. et al. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Ehses, S. et al. Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.
Zanna, C. et al. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.
Zhou, X. et al. Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Large dynamin-related Mfn1, Mfn2, and OPA1 constitute the core machinery promoting mitochondrial fusion.
Mitochondrial fusion and fission are critical to heart health; genetically interrupting either is rapidly lethal.
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