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A recent investigation also showed larger reduction of N-acetyl-aspartate levels in a functional MR spectroscopy study in MWA but not in MWoA [47] indicating a less effective mitochondrial functioning in MWA.
In the study by Sarchielli et al. [2], authors postulated that the greater decrease in NAA at baseline (before visual stimulation) suggested a less efficient mitochondrial functioning in migraine with aura compared with patients without aura, who, on the other hand, showed a slight but not significant NAA decrease during photic stimulation compared with controls.
As ClpQY is the only protease machinery localized in the mitochondria, it may be having an important role in the mitochondrial functioning in the apicomplexan parasites.
PIO-treated PS1-KI females also showed no statistically significant alterations in brain mitochondrial enzyme activity but significantly increased reverse LDH activity.PIO treatment produced no effects on cognition, glucose metabolism, or mitochondrial functioning in 3xTg-AD mice.
One consequence of impaired mitochondrial functioning in the HFD group may be perturbations in the physiological O2 gradient within the liver between the portal and central vein circulations leading to hypoxia.
Thus, while more work is required to understand whether and how the ND5 deletion directly affects mitochondrial functioning in C. briggsae, it is clear that there is no simple relationship between isolate-specific net ROS production and the detrimental phenotypes associated with high ND5 deletion heteroplasmy levels in nature.
Similar(53)
Generally, direct functional measurements of the effect of insulin on mitochondrial function in skeletal muscle are relatively scarce.
In the literature, the effect of NE on mitochondrial function in sepsis has been controversial.
Over the years, various studies have identified several modes of mitochondrial function in tumorigenesis.
This study aimed to determine the role of mitochondrial function in GNP radiosensitisation.
These studies suggest a potential circulating factor, directly affecting mitochondrial function in sepsis.
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