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We found that the metabolite-binding macrodomain was essential for sustained optimal mitochondrial function but dispensable for gene regulation.
Growing evidence links TXNIP to mitochondrial function, but the molecular nature of this relationship has remained poorly defined.
Depletion of prohibitins had no major effect on mitochondrial function but did affect adhesion of cells to the extracellular matrix.
These results indicated that ρ0 treatment perturbed mitochondrial function but did not change the quantity of mitochondria.
The results suggest that the decreased physiological performance as detected ex vivo (Figure 4) might not result from general impairment of mitochondrial function, but rather from uneven distribution of dysfunctional mitochondria in myocardial cells in Mecr transgenic mice.
Recent studies suggest that p53 plays an important role in maintaining mitochondrial function, but it is not known whether the oxidative stress status of the nucleus and mitochondria are differentially affected by p53.
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Current therapies for AD and PD might influence mitochondrial function indirectly, but few specifically target mitochondrial function.
We did not monitor markers of mitochondrial function per se but since the integrity of the mtDNA is intimately associated with proper mitochondrial function [45], [59] it is likely that mitochondria are further impaired in the cancer cells expressing NES-hTERT.
Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) supplementation partially attenuated the age-related decline in mitochondrial function in mice, but this effect was not observed with docosahexaenoic acid (DHA).
Neutralization of mitochondrial ROS is critical for mitochondrial function and, ultimately, cellular functions but low-level concentrations of ROS are also required for signal transduction [ 18].
They found changes in both groups in inflammation, energy metabolism, mitochondrial function and telomere maintenance, but experienced meditators had greater changes.25 Another study comparing experienced meditators to novices after 8 hours of meditation examined GE changes specific to epigenetic regulatory enzymes.
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mitochondrial fraction but
mitochondrial enzyme but
mitochondrial fragmentation but
mitochondrial state but
mitochondrial damage but
mitochondrial association but
mitochondrial enlargement but
mitochondrial transcription but
mitochondrial pool but
mitochondrial metabolism but
mitochondrial movement but
mitochondrial fission but
mitochondrial disease but
mitochondrial abundance but
mitochondrial level but
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