Sentence examples for mitochondrial fluctuations from inspiring English sources
In this study, we provide several new insights into the mechanism and significance of spontaneous mitochondrial fluctuations.
Developing ratiometric fluorescent probes for real-time detection of mitochondrial pH fluctuation is still highly demanded yet challenging.
The chemical nature and functional significance of mitochondrial flashes associated with fluctuations in mitochondrial membrane potential is unclear.
In contrast, DAB 3.0 caused a significant fluctuation in mitochondrial membrane potential only at 6 h, compared with other incubation times.
In this study, the authors identified common and organelle-specific lipid species and also found that the mitochondrial lipidome exhibits more temporal fluctuation than the nuclear lipidome [42].
Further, integration of mitochondrial signaling with nuclear transcription couples fluctuations in cellular energy needs with metabolic inputs.
Moreover, future studies will need to link specific markers of mitochondrial dysfunction and/or cerebrovascular impairment with fluctuations in lac concentration across aMCI individuals.
Moreover, it has been shown that, in addition to helping buffer large cytoplasmic Ca2+ fluctuations, the maintenance of optimal mitochondrial function is dependent on continual, constitutive Ca2+ transfer from ER to mitochondria to support oxidative phosphorylation [ 9].
However, mitochondrial DNA integrity is very sensitive to fluctuations in cellular dNTP levels (Zhao et al. 1998), and it is conceivable that dNTP homeostasis would be affected by impaired hexose metabolism in esl1 Δ esl2 Δ mutants.
It is possible that kinesin-1, the main mitochondrial motor protein [14], is more sensitive to fluctuations in ATP concentration than cytoplasmic dynein.
The demonstration that this compensatory mechanism occurs spontaneously in intact cells indicates that ΔΨm fluctuations are not an indicator of mitochondrial dysfunction as concomitant pHmito flashes preserve the proton-motive force, thus maintaining the ability of mitochondria to convert energy.
