Sentence examples for mitochondrial dysfunctional from inspiring English sources

Numerous signaling pathways, additional metabolic and mitochondrial dysfunctional pathways are also manifest, suggesting that a wide range of canonical pathways may be involved in the response to infection.

Mitochondrial dysfunctional has been widely reported with aging [ 54] and many age-related diseases [ 49].

Figure 8 shows, as an example, the complicated mitochondrial dysfunctional pathway.

The mitochondrial dysfunctional pathway was distributed within five regions of a cell - cytoplasm, outer mitochondrial membrane, intermembrane space, inner mitochondrial membrane, and mitochondrial matrix.

To further investigate a functional role of GPX1 activation in mitochondrial dysfunctional cells, we transfected the plasmid expressing nonspecific shRNA (NS-shRNA) and the plasmid expressing GPX1 shRNA (GPX1-shRNA) in Tet/off cells.

In response to mitochondrial dysfunction, OPA1 is proteolyzed to segregate dysfunctional organelles, impairing their fusion with the remaining chondriome [51].

When parkin becomes dysfunctional, the clearance of damaged mitochondria is prevented resulting in overall cellular mitochondrial dysfunction [ 4].

Mitochondrial dysfunction was also associated with increased expression of autophagic genes and the elimination of dysfunctional mitochondria with mitophagy.

Mitochondrial dysfunction observed in Parkinsonism or ESRD, may lead to high cellular oxygen tension since dysfunctional mitochondria consume little oxygen.

This condition would decrease MG-induced macromolecular glycoxidation, mitochondrial damage, dysfunctional signalling and gene expression, as described above.

Well-known pathogenic mutations render mitochondrial tRNA dysfunctional by disrupting their structures causing a variety of severe diseases [Wittenhagen and Kelley, 2003; Yarham et al., 2010].