To analyze the effects of GnRH agonists versus antagonists on mitochondrial distribution and activity in human mature oocytes.
Thus, understanding mitochondrial distribution, shape, and dynamics in all cell types is a prerequisite for developing and defining treatment regimens that may differentially affect tissues.
Vitrification significantly decreased the proportion of MII oocytes with normal mitochondrial distribution compared with the control and exposed groups (35.4%, 71.9% and 59.2%, respectively, P < 0.05).
Therefore, a major function of DISC1 in regulating mitochondrial distribution, ATP synthesis and calcium buffering may be disrupted in psychiatric disease.
However, no significant difference was observed between the cryoprotectant exposed and control groups with regard to the normal mitochondrial distribution or GSH content (P > 0.05).
We identified glycogen synthase kinase (GSK 3β dependent Drphosphorylationion at Ser40 and Ser44, which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation.
To detect the mitochondrial distribution, 50 nM MitoTracker CM-H2XRos were added during calcein loading.
All these features suggest a linkage between low developmental ability and perturbed mitochondrial distribution.
In elongating root hairs, mitochondrial density increased markedly while mitochondrial distribution showed a subapical to base gradient (Fig. 1E).
Nevertheless, the murine SirT3 was shown to maintain a paranuclear localization, consistent with a mitochondrial distribution pattern [12].
Thus, the altered mitochondrial distribution in cells ectopically expressing MULAN was apparently not due to microtubule disruption.
