Sentence examples for mitochondrial disruption from inspiring English sources

The ZnO dissociation disrupts cellular zinc hemostasis, leading to lysosomal and mitochondrial disruption, and finally cell death.

Mitochondrial disruption and a decrease in the amount of smooth endoplasmic reticulum were observed in Leydig cells.

The goal of this study was to investigate whether overexpression of mitofilin can limit mitochondrial disruption associated with the diabetic heart through restoration of mitochondrial morphology and function.

In conclusion, we have demonstrated that GHSC-74 inhibited growth of HepG2 cells by inducing S and G2 phase arrest of the cell cycle and by triggering apoptosis via mitochondrial disruption including both caspase-dependent and -independent pathways, and ROS generation.

Thus, not only platinum salts but also NP-Pt, via mitochondrial disruption, may lead to mitochondria-dependent apoptosis.

Exposure of BJ-hTERT cells to Cr VI) resulted in a dose-dependent increase in apoptosis that involved mitochondrial disruption as evidenced by mitochondrial membrane depolarization and cytochrome c release.

This observation was verified through Annexin V-FITC/PI assay and real-time high-content monitoring of cytosolic calcium, mitochondrial membrane disruption, and caspase-3 activation methods.

OPA1 cleavage in CGNs occurs coincident with extensive mitochondrial fragmentation, disruption of the microtubule network, and cell death.

And the induction of apoptosis by complex 1 in LNCaP cells is closely associated with mitochondrial function disruption and reactive oxygen species (ROS) accumulation.

Further, mechanistic studies in MDAMB-231 cells revealed that CH-OA-PLGA induces apoptosis by mitochondrial membrane disruption; follows ROS mediated and caspase dependent apoptosis.

One protein, called Bax, was known to induce mitochondrial membrane disruption in response to apoptotic signals.