Our results challenge the view that VDAC is the mitochondrial determinant of cell survival or death, acting as a hub that binds either anti- or pro-apoptotic Bcl-2 family members depending on the presence or absence of HK II, respectively [2].
Additionally, the possible role of glycolytic and non-mitochondrial determinants of hypoxia tolerance to these phenotypes is also being examined.
Mitochondrial internal determinants may also contribute to the assembly and position of Mic60, such as the mtDNA-independent replisome, which could function to coordinate cristae biogenesis with nucleoid placement (Meeusen and Nunnari, 2003).
Determining the connection between the genetic determinants of mitochondrial bioenergetics and hepatic TG accumulation could provide important insights into the etiology of NAFLD.
That a conserved mechanism governing such a tradeoff appears to have evolved actually supports the notion that mitochondrial ROS are important determinants of survival and life history choices.
Obviously, mitochondrial events are the determinants in AVO-induced cell death, and caspase-9 is a critical element in the transduction of the apoptotic signal, whereas the extrinsic pathway involving death receptors and caspase-8 is less important.
The results of the present study provide strong evidence that both the amount of cytochrome c in the IMS and its redox state are major determinants of mitochondrial ROS production under physiological conditions and may account for the increased ROS production in ischaemia and reperfusion.
The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure.
The protective effects of monoHER on cell cycle progression and molecular determinants of mitochondrial-dependent apoptosis were also studied.
Therefore, the presequence seemed to be the determinant for mitochondrial targeting, and the question arose whether the Par17 N-terminus was necessary and/or sufficient for mitochondrial targeting.
Although human PHB1 does not possess the MTS, the N-terminal portion of PHB1 is also the sole determinant of mitochondrial targeting [ 2].
