Sentence examples for mitochondrial changes and from inspiring English sources
Furthermore, the mitochondrial changes and longevity effects induced by CA are conserved across different species.
These post-hoc analyses show that this apparently heterogeneous group of ICU patients behave rather consistent with regard to mitochondrial changes and gene expression in skeletal muscle.
Genes involved in DNA replication, chromosome condensation and segregation are also overrepresented among genes with decreased expression at P13, as are those for of cyclin-dependent protein kinase inhibitors, apoptotic mitochondrial changes and nucleoporins.
Most tumor cells displayed ultrastructural features characteristic of hypoxia, i.e., mitochondrial changes and dilated endoplasmic reticulum (ER) cisternae without ribosomes.
Mitochondrial changes and increased sarcolemmal and sarcoplasmic MHC class I staining were observed in all six IBM cases, but not in normal controls.
Interestingly, these alterations are reminiscent of those observed during cell dedifferentiation, including an increase in myocyte volume, myolysis, glycogen accumulation, mitochondrial changes, and chromatin redistribution [ 38].
Clumping of nuclear chromatin, appearance of I-bands in myocytes, and mitochondrial changes (swelling and dense material deposit) tended to be lower in 2 μg/mL propofol compared to control and to 10 μg/mL propofol and 4(b)).
The axonal degeneration and mitochondrial changes were extensive and were observed both in subepidermal Remak Schwann cells and in small distal cutaneous nerves (Fig. 6B).
Thus, the role of mitochondria and Ca2+ is an essential determinant: Ca2+ loads in the matrix sensitize the mPTP to apoptotic stimuli, inducing its opening, mitochondrial changes in morphology, and the release of cytochrome c [50] and caspase activation [51,52].
Interestingly, the increased entry of substrate into the TCA cycle also increased expression of PGC1α, which may have coordinated the functional and mitochondrial changes observed with pyruvate, DCA, and glutamine.
These experiments strongly suggest that oxidative stress lies at the root of the ER and mitochondrial changes caused by Miner1 deficiency, and importantly that sulphydryl anti-oxidant treatment could be a rational therapeutic approach for treating this syndrome.
