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However, modifying device design to allow for greater nerve penetration, as well as mitigating the inflammatory response to such devices, would likely increase device performance and should be investigated in future research.
In vitro tests showed that TiO2 nanotubes exhibited significantly decreased inflammatory activity of macrophages with respect to cytokine and chemokine gene expression/protein secretion, induction of foreign body giant cells (FBGCs) and nitric oxide (NO) release thereby mitigating the inflammatory response induced by LPS as compared to flat Ti surface.
Therefore, lactoferrin and its fragments in milk may be responsible for mitigating the inflammatory response to the HFM meal compared with the HFD meal.
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However, only the NO-release materials capable of releasing low NO fluxes (0.8 3.3 pmol cm−2 s−1) for 7 13 d durations mitigated the inflammatory response at 25 d.
Topics considering the approaches to mitigate the inflammatory response, use of biomimetic chemistries, nanostructured topographies, drug eluting constructs, and tissue-to-device interface modulus matching are reviewed.
The ability of this gel to mitigate the inflammatory response in cell transplantation strategies was evaluated using cell-surrogate polystyrene microparticles suspended in the nanofiber gel that were then subcutaneously injected into mice.
Lower avidity interactions with host cells might also mitigate the inflammatory potential of the remaining sequestered parasites.
The use of NSAIDs could potentially mitigate the inflammatory effect of ovulation, possibly at the site of ovarian inclusion cysts.
In this setting, ACPAs might preferentially activate inhibitory Fcγ-receptors and thus mitigate the inflammatory response [ 29].
25– 27 Thus, low synthesis and availability of AA have been suggested to mitigate the inflammatory response by altering, for example, eicosanoid levels.
These data are consistent with the hypothesis that the down-modulation of IL-6 signaling might be sufficient to mitigate the inflammatory response in dystrophic muscles and, possibly, to attenuate the muscle phenotype observed in adult mdx mice.
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