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Since over half of SoxRS dependent genes identified in the three main clusters have no known function, it is possible that the SoxRS system is part of a larger xenobiotic response system, and regulates many genes that are not necessary for repairing or mitigating oxidative damage.
When skin is exposed to UV light stress, more skin lycopene is destroyed compared with β-carotene, suggesting a role of lycopene in mitigating oxidative damage in tissues.
Three of these, DPSL, superoxide dismutase, and peroxiredoxin were shown to interact and likely form a novel supramolecular complex for mitigating oxidative damage.
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Hence, TNJ may also mitigate oxidative damage and consequent lipid peroxidation in cigarette smokers.
Serine hydroxymethyltransferase (SHMT; Unigene2603 and Unigene1010) are involved in the photorespiratory pathway and plays an important role in plants to minimize the production of ROS in chloroplasts and mitigate oxidative damage [ 40].
Hydroxymethyltransferases play a critical role in controlling the cell damage caused by abiotic stresses such as high light and salt, supporting the notion that photorespiration forms part of the dissipatory mechanisms of plants to minimize production of reactive oxygen species (ROS) in the chloroplast and to mitigate oxidative damage [ 39].
AKR and PMSR have established roles in mitigating oxidative protein damage.
This may include mitigating deleterious oxidative damage to their sperm, and so be directly related to their functional fertility.
Our study provides novel methods to mitigate oxidative stress induced damage in cryopreserved sperm for future applications.
Although hypothermia cannot completely diminish free radical production in injured cells, it can significantly reduce the amount of free radicals enough to allow for the endogenous antioxidant mechanisms to mitigate the oxidative damage.
The seed extracts have also been shown to mitigate the oxidative damage in calf thymus DNA.
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