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It is not known whether administration of either anti-emetic agent alone would suffice in mitigating nausea and/or vomiting.
Gradual dose escalation at initiation of exenatide therapy is recommended, having been shown to be effective at mitigating nausea and vomiting with no loss of glucoregulatory activity [ 7].
Gradual dose escalation was shown to be effective in mitigating nausea and vomiting in an earlier study [ 7] and was therefore used in the development of the treatment protocol for exenatide (5 μg for the first month, followed by 10 μg).
Similar(57)
An MIT-designed adjustable comfort-level system mitigates nausea through designed locomotion systems and customized training sequences, leading to smoother gaming, mainly on Oculus, Vive, and PSVR platforms.
32, 33 The ability of antiemetics to mitigate nausea associated with antidiabetic agents is unknown given the paucity of data available on this subject in the literature.
While the study utilized anti-emetics primarily for subject retention purposes, because the study medication was not titrated, this post hoc analysis was performed to evaluate their effectiveness in mitigating the nausea and vomiting associated with exenatide treatment and their effect on the pharmacokinetics of exenatide.
The results of this analysis represent the first published data demonstrating the effectiveness of oral anti-emetic medications in mitigating exenatide-induced nausea and vomiting.
Overall, IDegLira offers simple titration of two efficacious therapies in a single daily injection while mitigating the principal side effects of basal insulin (hypoglycemia and weight gain) and GLP-1RA (nausea) when given alone [ 55, 56].
The combination has the potential to provide improved overall glycemic control whilst mitigating some of the common side effects experienced with GLP-1RAs and basal insulin (e.g., nausea, weight gain, and hypoglycemia).
No mitigating epithets allowed.
Incentives are critical to mitigating system risk.
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