The inability to capture conditions that contributed to, or mitigated, individual-level exposures including access to air conditioning or shade may have introduced additional exposure misclassification that the data could not address.
There are at least three processes through which adverse health effects of industrial development projects can be mitigated at community level, and which would apply directly to oil extraction.
When iberiotoxin was added, the loss of ATP was almost completely mitigated, but ATP levels were not restored to control levels.
Dystrophin expression at ~20% of the wild-type level significantly mitigated muscle pathology and enhanced muscle contractility (Phelps et al., 1995; Wells et al., 1995).
Tam also promoted adipocyte dedifferentiation and ROS production, whereas normalization of ROS level markedly mitigated Tam-induced adipocyte dedifferentiation, apoptosis and autophagy, concomitant with restoration of mature adipocyte population and fat mass.
Vitamin B6-deficient Arabidopsis leaves were more sensitive to treatments with the O2 generator eosin than WT leaves, and exogenous application of vitamin B6 reduced O2 level and mitigated lipid peroxidation in leaf discs exposed to high light.
During general anesthesia of healthy individuals, the risk of transient psychomotor and cognitive dysfunction is increased with exposure to hypocapnia [ 34], and mitigated by higher PaCO2 levels during anesthesia [ 35].
The second scenario indicates the level of mitigation required to suppress beetle infestations where the proportion of mitigated trees was calculated for each plot by counting the residual attack and the number of mitigated trees.
DNA repair mechanisms were robust, but increased DNA damage delayed repair; this effect was mitigated for cells carrying high levels of DNA damage but cultured on fibronectin.
Correspondingly, enhancing neuronal cathepsin activity significantly decreased Aβ levels and accumulation, mitigated autophagic-lysosomal pathology, and improved cognition in transgenic mice overexpressing APP [ 40, 41].
