Sentence examples for mitigate the pathology from inspiring English sources

Perhaps similar genetic targeting of Purkinje neurons in the cerebellum of existing mouse models with IC-G2736X could mitigate the pathology of SCA1, SCA2, and SCA3.

Thus, despite SIL1 disruption, the residual GRP78 function in the PCs of the woozy mice could mitigate the pathology and rapid loss of cerebellum function due to complete lack of GRP78 in the tipsy mice.

We therefore reasoned that Opa1 overexpression could be exploited to correct the biochemical impairment and mitigate the pathology associated with genetically determined OXPHOS failure in available mouse models of mitochondrial disease.

A proper autophagy capability in the liver may be crucial to reduce the detrimental effects of cholestasis, and that enhancement of autophagy may be a possible therapeutic strategy to mitigate the pathology associated with cholestasis liver disease.

Using two mouse models with distinct AD-related pathologies (tau pathology in K3, amyloid pathology in APP/PS1), we report evidence that NIr treatment can mitigate the pathology characteristic of AD as well as reduce oxidative stress and restore mitochondrial function in brain regions affected early in the disease.

The aim of this study was to assess the efficacy of NIr in mitigating the brain pathology and associated cellular damage that characterise AD.

Primary care providers can modify the pathology and mitigate the expression of disease through prevention and treatment [ 13].

They can influence the effects of pathology, mitigate the extent of any resulting disability, prevent excess disability and reduce the risk of social exclusion [ 10].

Despite growing evidence that the progressive disequilibrium of neuronal Ca2+ contributes to the pathology of AD, available treatments that can mitigate the deleterious effects of Ca2+ overload in the brain remain limited.

Thus, in order to improve the management of glaucoma and mitigate the associated risk of blindness, it is important to improve our understanding of the pathologies that lead to deterioration in vision independently of IOP.

For this we excluded all speech-language pathology notes as the purpose of the majority of these notes were to describe therapy to address and mitigate the communication disability, and therefore would skew our results.