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Several studies have described how behavioral reversals could mitigate the gains from vaccination or even produce perverse outcomes where the use of the vaccine results in more infections [8], [37] [39].
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This quality could mitigate the weight gain associated with insulin therapy and might be further enhanced through any reductions in insulin dose.
Low-dose metformin could not mitigate the weight gain associated with rosiglitazone in a recent RCT [ 52], although its effect seems likely to be through weight loss in the small number of treated patients [ 53].
8, 17 Body weight reduction associated with SGLT2 inhibitor use can mitigate the weight gain accompanying pioglitazone and insulin, which was demonstrated when dapagliflozin was added to pioglitazone or insulin therapy.
Delays at any of these steps may mitigate the positive time gains resulting from the increased MD/MO availability due to the CD4 nurse intervention.
Although weight gain was viewed as less important than quitting, many talked about changes they had made to mitigate the anticipated weight gain.
This communication/synchronization overhead may easily mitigate the positive effects gained by parallelization.
Clinicians can help mitigate the potential weight gain temporally associated with olanzapine treatment by being aware of the patient's characteristics like baseline BMI and baseline level of interest in food, and monitoring the patient early in treatment for weight gain, changes in appetite or hunger, or cravings for carbohydrates, and for reduced cognitive restraint.
Regular physical activity may help to mitigate the tendency for weight gain and adverse changes in body composition and fat distribution that accompany aging and the menopausal transition (39).
The safety hypothesis for a trial combining pioglitazone with dapagliflozin would not be anticipated to worsen the pioglitazone-related side effects and, because dapagliflozin causes glucosuria, which drives diuresis and caloric loss, it may mitigate the concerns of weight gain and fluid retention/edema.
10 Metformin, when used as cotherapy, also mitigates the weight gain seen with sulfonylureas and repaglinide.
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