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A crucial issue in developing DMD therapy is to determine the minimal levels of dystrophin needed to mitigate the clinical manifestation.
Prompt action to mitigate the clinical and societal effects of the pandemic was taken by many countries, including surveillance on probable H1N1 cases, airport fever screening, quarantine, and antiviral therapy on probably cases [5].
In particular, MDMA treatment is under study to mitigate the clinical symptoms of PTSD [ 2].
Alternatively a genomic test may identify a genotype with incomplete or variable penetrance, or the harms (or other tradeoffs) of testing outweigh or mitigate the clinical benefits.
Factors that modulate the inflammatory process might be key to mitigate the clinical symptoms and improve the performance of affected fish.
In this specific context, the F167L mutation does not mitigate the clinical phenotype, which is characterized by severe generalized myotonia and muscle stiffness; whether P558S may exert a dominant negative effect on F167L would require further investigation.
Similar(54)
The absence of hydronephrosis on ultrasound predicts easier passage of calculi, thereby mitigating the clinical need for further evaluation [326].
The outcome of this infection in humans is often fatal, but if the infection is recognized and treatment initiated early, larvae may be killed before they enter the central nervous system, thus mitigating the clinical disease or preventing death (14 ).
In recent years, antiviral therapy has become available to mitigate the risk of clinical complications following congenital CMV infections [39], but apart from the serious potential side effects, this option may not be affordable to populations in low income countries.
A greater understanding of amyloid clearance will be required for the development of targeted therapies to mitigate the risk and clinical progression of AD.
However, there is potential to mitigate the challenges of PROMs-clinical data linkage by using the UK's network of cancer registries which collate and store clinical data on all cancer patients [ 17]; English data are additionally pooled and stored by the National Cancer Intelligence Network in the National Cancer Data Repository (NCDR) [ 18].
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