Sentence examples for mitigate the activation from inspiring English sources

In turn, IGF-1R inhibition could mitigate the activation of upstream signaling molecules that occurs with mTOR inhibition.

Gadd34 encodes a regulatory subunit of an eIF2 α-directed phosphatase complex that serves as a regulatory loop to mitigate the activation of PERK.

Subsequent mechanistic studies revealed that sulforaphane mitigated the activation of signal transducer and activator of transcription 1 induced by Aβ1 42 monomers.

In the kidney, p53 activation after ischaemia-reperfusion injury mitigates the activation of the protective HIF-1 pathway by decreasing HIF-1 α protein level.

The beneficial effects of HR on liver grafts have also been shown in transplantation of nonsteatotic pig livers, where hepatocellular autophagy was preserved, mitigating the activation of innate immunity and leading to an improved survival of recipients [ 36].

However, a decoy mechanism is found in which AGEs and other ligands (14) bind to RAGE a circulating form of RAGE and thereby preclude access of the RAGE ligand to sRAGE mitigating the activation of the pathways of oxidative and nitrosative stress.

For both the original compositions as well as the revised one with reduced amount of impurities, suggested to mitigate the waste impact, activation calculations have been performed.

The initial activation of Lyn is essential for the activation of mast cells, and Lyn additionally also has a negative role in mitigating the excess activation of mast cells [ 14].

At last, the effect of PF11 on neuroinflammation was confirmed in vivo: PF11 mitigated the microglial activation and proinflammatory factors expression obviously in both cortex and hippocampus in mice injected intrahippocampally with LPS.

When hypoxia is followed by a reoxygenation phase, p53 can be upregulated during this latter phase and promote apoptosis, mitigating the concomitant activation of the protective HIF-1 pathway.

By this analysis the radiation streaming pathways and dominant sources of decay radiation were revealed and the methods to mitigate the streaming and subsequent activation were found.