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Our finding that increasing macrophage supply after granulomas have formed can mitigate susceptibility may suggest the therapeutic potential of myeloid growth factors for TB.
We used this line to ask if restoring macrophage supply by shifting infected animals to the permissive temperature soon after granulomas formed could mitigate susceptibility.
Consistent with the QA data, MSNs from symptomatic mice showed decreased NMDA (N-methyl d-aspartate) currents compared with age-matched controls, suggesting that in addition to aging, cell-autonomous mechanisms mitigate susceptibility to excitotoxicity in the symptomatic stage.
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To mitigate the susceptibility to various viruses (e.g. human immunodeficiency virus, HIV), primates have evolved innate cellular defense systems to inhibit virus replication in cells or virus release from cells.
Furthermore, because early maturing varieties are used as a drought escape strategy in rain-fed production systems, the introgression of non-maturity related resistance loci will be required to mitigate their susceptibility.
The relationship between material deprivation and children's health is complex because financial resources do not straightforwardly buy health, although higher incomes facilitate access to better housing quality and location that may mitigate illness susceptibility and severity.
Continued surveillance of gonococcal antimicrobial susceptibilities is vital to inform treatment guidelines and mitigate the spread of isolates with decreased susceptibility to cephalosporins and resistance to azithromycin.
The exact role of sex steroids and whether fluctuations (eg. androgens in cardiovascular disease and estrogen in AD) or absolute levels of hormone may mitigate some degree of disease progression and susceptibility to depression remains unclear.
We further demonstrate the utility of this organoid system for modeling the teratogenic effects of Zika virus on the developing brain and identifying more susceptibility receptors and therapeutic compounds that can mitigate its destructive actions.
This suggested that SFAR4 disruption enhanced the susceptibility to glucose, whereas SFAR4 overexpressors could partially mitigate this effect during seed germination.
Additionally we examined whether inducement to consider typical performances could mitigate the effect (robustness), and whether confidence in judgments predicted susceptibility to the effect (insight).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com