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32, 33 The ability of antiemetics to mitigate nausea associated with antidiabetic agents is unknown given the paucity of data available on this subject in the literature.
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It is not known whether administration of either anti-emetic agent alone would suffice in mitigating nausea and/or vomiting.
Gradual dose escalation at initiation of exenatide therapy is recommended, having been shown to be effective at mitigating nausea and vomiting with no loss of glucoregulatory activity [ 7].
Gradual dose escalation was shown to be effective in mitigating nausea and vomiting in an earlier study [ 7] and was therefore used in the development of the treatment protocol for exenatide (5 μg for the first month, followed by 10 μg).
While the study utilized anti-emetics primarily for subject retention purposes, because the study medication was not titrated, this post hoc analysis was performed to evaluate their effectiveness in mitigating the nausea and vomiting associated with exenatide treatment and their effect on the pharmacokinetics of exenatide.
The results of this analysis represent the first published data demonstrating the effectiveness of oral anti-emetic medications in mitigating exenatide-induced nausea and vomiting.
This strategy should mitigate the significant limitation of anticipatory nausea.
Anti-nausea or anti-diarrheal drugs were allowed to mitigate side effects if necessary.
Furthermore, the altered biodistribution and pharmacokinetics substantially mitigate many of the typical toxicities of bolus doxorubicin administration, such as nausea and alopecia, while inducing alternate toxicities.
69 73 Potential adjunctive therapies to mitigate AEs include folate supplementation, which reduces MTX-associated hepatic AEs, 50 74 and antiemetics, which suppress MTX-induced nausea and vomiting.
For example, if nausea is experienced in the morning, delaying or reducing the morning dose to one or two capsules, may help mitigate GI symptoms.
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