Sentence examples for mitigate activation of from inspiring English sources

These results demonstrate the potency of the OxySite material to mitigate activation of detrimental hypoxia-induced pathways in islets during culture and highlights the importance of in situ oxygenation on resulting islet transplant outcomes.

In turn, IGF-1R inhibition could mitigate the activation of upstream signaling molecules that occurs with mTOR inhibition.

Gadd34 encodes a regulatory subunit of an eIF2 α-directed phosphatase complex that serves as a regulatory loop to mitigate the activation of PERK.

Subsequent mechanistic studies revealed that sulforaphane mitigated the activation of signal transducer and activator of transcription 1 induced by Aβ1 42 monomers.

In the kidney, p53 activation after ischaemia-reperfusion injury mitigates the activation of the protective HIF-1 pathway by decreasing HIF-1 α protein level.

These effects of alcohol can be mitigated by activation of Nrf2, suggesting a potential therapy in individuals at risk for lung injury due to alcohol abuse.

The beneficial effects of HR on liver grafts have also been shown in transplantation of nonsteatotic pig livers, where hepatocellular autophagy was preserved, mitigating the activation of innate immunity and leading to an improved survival of recipients [ 36].

However, a decoy mechanism is found in which AGEs and other ligands (14) bind to RAGE a circulating form of RAGE and thereby preclude access of the RAGE ligand to sRAGE mitigating the activation of the pathways of oxidative and nitrosative stress.

Such cellular oxidative stress can be mitigated by the activation of antioxidant systems [ 68].

When hypoxia is followed by a reoxygenation phase, p53 can be upregulated during this latter phase and promote apoptosis, mitigating the concomitant activation of the protective HIF-1 pathway.

The main problem for this category of bone substitutes is low osteoinductive potential, which surgeons often mitigate using an improvised, empirical activation of mixing the material with the patient's blood, autogenous bone (generally, in a ratio of 1 : 1), plasma enriched with thrombocytes, or plasma enriched with growth factors immediately prior to implantation [ 211].