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Errors in crossover are especially likely when similar sequences cause partner chromosomes to adopt a mistaken alignment; this makes some regions in genomes more prone to mutating in this way.
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It is important to remember that the described process not only results in term translations but that it also entails the process of identifying possible term candidates as well as weeding out mistaken alignments and alignments which cannot be deemed as terms of the domain in question.
It is also worth noting that indels at the ends of reads may not inhibit alignment and can in some instances be mistaken for SNPs in downstream analyses.
In such a case, primers issued from PHYLORPH could either target the mistaken paralog resulting in gene/species tree discrepancies or multiple paralogous copies that will complicate amplification, sequencing and alignment.
Moreover, because PA variant detection depends on the alignment stringency, the highly divergent GBS tags representing different alleles of the same locus can be mistaken for two independent PA loci.
Bias mistaken for accuracy.
We may be mistaken.
Well, we were completely mistaken.
Simple mistakes, like improper alignment or poor posture over the ball, are obvious even to hackers.
This measurement should avoid alignment mistakes between the polarization direction of the incoming light and the polarizer, since minor changes in the value of the TE polarization can significantly effect the extinction ratio.
A sample of alignments was checked manually for obvious alignment mistakes, none were found, and consequently the alignments were not edited further.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com