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We imputed missing visit costs as the mean non-missing visit cost of all children in the trial using data on the number of study visits each child attended.
For patients with one missing visit, values from the previous visit were carried forward to impute the values of the missing visit.
The association between biomarker groups and missing data was modeled using generalized mixed-effects regression with a binomial indicator for a missing visit.
Subjects were excluded (n=2327) from the original inception participants for incomplete data, dental implants only and missing visit 4 screening.
If a composite measure of disease activity was missing for one observation between two observed visits in REM, we assumed that the patient had also been in REM at the missing visit.
For children who miss this visit, the health workers will visit their house to complete the follow-up examination and collect blood samples within a month of the missing visit.
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Subjects with missing visits or who were lost to follow-up at any time during the study were considered as smokers.
In both trials, participants missing visits were contacted by phone or by fieldworker visit.
The DCC will send weekly email reports with information on missing data, missing forms, and missing visits.
This resulted in a small number of calves missing visits for one or two 5 weekly visits.
This may result in a small bias in the estimates of the effect of missing visits on mortality.
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