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Also, our manual review of all case patients should reduce misclassification of cancer, although a number of missing values remained on specific histology and subsite.
A regression model with pairwise exclusion failed where missing values remained for the ACD variables, therefore these cells were replaced with mean values, the ensuing model resulting in an almost identical model to that obtained when excluding these two variables.
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We also eliminated all the probes with missing values, remaining 13,188 probes.
Imputation of remaining missing values: remaining missing values were imputed using sequential K-nearest neighbor (SKNN) imputation (Kim et al., 2004 ) with k =5.
Missing values of remaining genes were imputed using an algorithm based on Principal Component Analysis [16].
The missing values of remaining genes were imputed via KNN method which uses nearest neighbour averaging.
Missing values of remaining items were imputed by a hot-deck procedure: the average value of a subset of comparable cases (respondents with the same profession, same working hours, and being part of management or not) was imputed for the missing values.
There were no missing values in the remaining questionnaires.
Missing values for the remaining variables were imputed to the median value.
Missing values of the remaining 4881 SNPs were imputed with R/synbreed [ 40].
Missing values for the remaining participants were replaced with item means.
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CEO of Professional Science Editing for Scientists @ prosciediting.com