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The missing values of the original data were filled by half of the minimum value via a numerical simulation method.
This section also introduces a generalized formula to combine the matching and missing values of two taxonomy trees.
Next, the missing values of both background variables were imputed using the R package MICE (van Buuren & Groothuis-Oudshoorn [2011]).
Due to the retrospective design of this study some missing values of the parameters was one of our limitations.
We accounted for missing values of baseline variables with multiple imputation techniques [25].
Missing values of remaining genes were imputed using an algorithm based on Principal Component Analysis [16].
The missing values of the categorical independent variables were replaced with the hot-deck method [31].
Because of such a high proportion, we did not exclude those cases with missing values of tumor grade.
Totals may differ due to missing values of some variables.
Missing values of <1.5% were not listed in the table.
n = 602, due to missing values of age at menopause.
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