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Because actinobacterium abundance scores were only obtained from day 11 and onwards, and because of missing values after day 21 in some pairings (See Tables 3, 4), the repeated measures ANOVA was performed only on days 11 21.
Missing values after 4 weeks were imputed using last observation carried forward method.
The initial number of missing values after the above prefiltering was 60.8%.
Remaining missing values after imputation (42.2%) represent truly absent peptides in the samples and were typically imputed by taking an estimate of the background noise.
To avoid missing values after log-transformation, any signal which was still less than 0.5 was reset to be equal to 0.5.
The proportion of patients achieving clinically meaningful improvements in each PRO was obtained using logistic regression and by applying non-responder imputation to missing values after rescue medication or withdrawal.
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end{aligned} (4 On this paper Lagrange interpolation is applied to interpolate when there is only one missing value in variable values or left with one missing value after other methods are employed.
However, due to the complication of the formula this method is employed when there is only one missing value in variable values or left with one missing value after other methods are employed.
A missing value after a session was replaced with the according pre-session value.
MAR means that the fact the data are missing is independent of the actual missing value, after accounting for other observed participant characteristics.
For eCrCl, missing values (typically after Day 7, due to ICU discharge) were imputed from last-observation-carried forward (LOCF).
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