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Having struck out with the authors of the disputed Kaiser paper and the two other published trials, Dr. Jefferson approached Roche itself, asking for the underlying data from the missing trials.
Otherwise, the missing trials were conducted on the next day.
If subjects terminated a session pre-maturely, the missing trials were conducted on the next day, up to a maximum of 12 trials per session.
However, the trim-and-fill computation revealed that there were no missing trials, indicating that the publication bias did not interfere with the interpretation of the results.
The forest plots for the meta-analyses were reproduced, both with and without data from the missing trials, and the results compared to see if omission would make any important difference.
Two consequences of missing data were found: 1) In three reviews [ 13- 15], the missing trials were the only ones providing data for seven (of a total 35) outcomes, so no data were available for these seven outcomes.
Similar(51)
David Cameron, when asked about missing trial results and Tamiflu, at prime minister's questions, explained that he took this problem seriously, and suggested new EU legislation will fix it.
Research shows that the alternatives are working, saving cities money as well as dramatically lowering the rates of people re-offending or missing trial dates.
If summary data are missing, trial authors will be contacted.
The influence of missing data was examined by replacing missing trial HbA1c values with routine clinic values where possible.
In two reviews [ 6, 7], each with one missing trial, the data used in the meta-analyses were available in two other papers; both were in CENTRAL, and included in the reviews.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com