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These are unclear because we do not know the impact of missing symptoms data, and the reports contained unclear definitions for secondary complications of influenza and a seemingly problematic decision tool for the alternative designation of events as either complications or harms, which we called 'compliharms' in our Cochrane review.
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Missing symptoms or laboratory data were counted as screen negative which may have introduced biases.
There was high risk of bias for included outcomes as a result of missing data (symptoms), selective reporting (influenza outcomes), potentially active placebo (harms), lack of outcome definitions (complications of influenza), suboptimal measurement (complications), and incomplete reporting in the clinical study reports.
When extracting data from the electronic database, we excluded all missing data, including missing data on accompanying symptoms.
Because no significant effects were found for predicting participant attrition at 6M-P, 10M-P, 14M-P, or 24M-P from 3M-P GAD or MDD symptoms, data were considered missing at random 33 and were accommodated using full information maximum-likelihood estimation.
For questions relating to individual health symptoms, missing data varied between 0.8% to 3.4%.
However, 726 women were excluded due to missing data on symptoms of depression (Malaise Inventory score).
Briefly, at each of the three data cycles, we excluded participants who had prevalent or previous depressive symptoms at baseline or missing data on depressive symptoms at baseline or at follow-up.
The validity was assessed by measuring levels of missing data, comparing symptom scores with objective prolapse stages and between affected and asymptomatic women.
Of the 124 observed eldercare workers, 25 did not respond to the questionnaire, 2 had missing data on depressive symptoms, 1 scored 50 points on the depressive symptom scale indicating a likely incorrect completion of the questionnaire and 1 had missing data on cohabitation, yielding a final individual level sample of 95 eldercare workers.
Of the 317 respondents, 81 were not female SH or SA working day or evening shifts; 24 belonged to a work unit that had not been observed; 2 had missing data on depressive symptoms; 1 scored a probably incorrect score of 50 points on the depressive symptom scale; and 4 had missing data on cohabitation, yielding a final work unit averaged sample of 205 eldercare workers.
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