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Therefore, in addition, we have used two different sensitivity analysis approaches for handling potential bias arising from missing stage information, bearing in mind different assumptions about the potential mechanisms generating missing data.
Two cases had missing stage information.
Text fields were not analyzed to determine whether they contained missing stage information.
Age standardized 5-year RS of BRC patients with unknown or missing stage information was varying in both countries.
The cases with complete stage information were used to derive data sets with simulated missing stage information.
Finally, older age is associated with both a greater risk of advanced stage at diagnosis and missing stage information.
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Compared with all other age groups, the proportion of women with missing staging information was higher among those aged ⩾75 years.
There were 9,712 tumors (9.9%) missing stage or grade information; these tumors were included in all analyses except for stratified analysis by aggressiveness of disease.
Furthermore, SCC patients had more frequently missing stage and treatment information, more often received no or symptomatic treatment (except in breast cancer) and had more frequently a history of any autoimmune disease (see Additional file 2: Table S2).
Of the 225 cases selected, there were 28 patient records lacking some aspect of clinical information: 14 missing tumor size, 16 missing nodal status and 4 missing stage of disease.
In this analysis, different variants of multiple imputation were studied, with respect to their feasibility and appropriateness for the imputation of missing values in tumour stages, limiting our analysis to one cancer entity with a high number of cases with missing tumour stage information and one cancer entity with only few missing tumour stage data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com