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A trend towards reduced decline, narrowly missing significance, was also observed on the praxis higher-order subscale of the SIB in rivastigmine-treated patients compared with placebo (rivastigmine, -0.33 (0.45); placebo, -1.43 (0.46); P = 0.051).
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n.s. for missing significance.
The bone, which was found in a cardboard box in the Winchester museum store, was in a heap of animal bones and some human fragments excavated from the abbey site in 1999, but its significance was missed and it wasn't analysed until within the past year.
In cases with synchronous metastasis versus those without, significant upregulation of miR-21 (p=0,02) and a trend towards downregulation of miR-126 missing the level of statistical significance was found (p = 0.08).
For heavy smokers significance was slightly missed (pBWS-Test = 0.089).
Unlike the other five categories, not every participant contributed to this category, and its significance was originally missed.
There was a trend for more severe cortical thinning in patients with high compared to normal serum lactate levels, but significance was narrowly missed (P = 0.061).
Concerning EQ-5D-3 L, they found that HRQL (summary index) is lower in the low SES group, but the 5% level of statistical significance was clearly missed.
With respect to upper leg body composition, we observed comparable effects, although statistical significance was just missed (P=0.050) for upper leg fat mass.
Even though statistical significance was only narrowly missed for the primary outcome measure (p= 0.06), a change in average FLACC score from 4.3 (no pacifier) to 2.5 (pacifier) would be considered by most to be of clinical significance.
However, statistical significance was reached for only one outcome measure and was not robust for different assumptions regarding missing data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com