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Likely missing significance due to small patient numbers, they also demonstrated the highest prevalence of het-norm/low (Table 1).
Densitometry (figure 2c) reveals significant differences in the amount of LMW fragments between normal and AD(4/4) brains and between AD 3/3) and AD(4/4) brains, with the difference between normal and AD 3/3) narrowly missing significance, (3 way ANOVA P<0.0001, Bonferonni-Dunn post-hoc test: control vs AD 3/3), p<0.05; control vs AD(4/4), p<0.0001; AD(3/3) vs AD(4/4), p<0.0001).
n.s. for missing significance.
The missing significance between overweight and obesity and diabetes among men may be due to the lower prevalence of diagnosed diabetes in men compared to women.
However, the major unresolved roadblocks include: big solution space but a small sample size; highly complex networks; imperfect prior knowledge; missing significance assessment; and heuristic structural parameter learning.
As expected, expression patterns of paralogs showed strong agreement across the ten transcriptomes, even if a gene was not captured by our biclustering approach due to missing significance in the pairwise differential expression analysis.
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The comparison between both groups missed significance by a narrow margin (p=0.054).
Notably, the comparison between improvement in patients with trigeminal neuralgia and persistent idiopathic facial pain missed significance by a narrow margin.
TKTL1, MAGEA5 and MAGEA3 also showed a positive correlation between demethylation and expression, but missed significance (Table S3).
TKTL1 (p = 0.1), MAGEA5 (p = 0.104) and MAGEA3 (p = 0.2) also showed a positive correlation between demethylation and expression, but missed significance (Table S3).
Two additional targets slightly missed significance at α<0.05, SBSN (p<0.07) and NY-ESO-1 (p<0.09) (2 tailed Student's t-test assuming unequal variance).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com