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Martelli, A. Velardi, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, in press].
It is now known that the MHC makeup on the surface of those cells is altered and the NK cells become activated through recognition of "missing self".
Murine natural killer (NK) cells express inhibitory Ly49 receptors for MHC class I molecules, which allows for "missing self" recognition of cells that downregulate MHC class I expression.
In this manner, loss of class I MHC protein from the surface, i.e. "missing self", can render cells susceptible to NK lysis [9], [10], [11], [12].
A presumed reason for this under-representation would be that NK cells with too high affinity for self MHC class I are excluded from the repertoire, as they would be less sensitive to normal cells with downregulated MHC class I expression (missing self recognition).
NK lymphocytes are capable of killing cells with missing self (that is, HLA class I expression).
Similar(35)
After setting very public goals, such as reducing greenhouse gas emissions, conserving water and cutting energy usage, many large corporation are falling behind or missing self-set benchmarks.
For every 10 low-key labourers, there must be at least one Louis Quatorze, with a missing self-awareness lobe and slightly more ambitious plans for their "brand" than Apple.
The most common reason for not matching trips was missing self-reported data (e.g., date, start or end time).
After repeatedly missing self-imposed deadlines for progress on its wireless charging-at-a-distance phone case, uBeam's CEO Meredith Perry has decided to shift out of the CEO position and into a board member and senior advisor role.
a Excluding four trips with missing self-reported distance.
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