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There were missing responses at KNH (5.3%).

As has already been noted, Midlands/Wales exhibited a larger proportion of missing responses at baseline for the covariates of interest.

A 'carry-forward' approach was applied in intention-to-treat analysis to handle missing responses at 3-, 6- and 12-month follow-ups [ 22].

QLQ-C30 set: defined as all ITT patients having an assessable QLQ-C30 (<50% of missing responses) at baseline, FACIT-CCSQ set: defined as all ITT patients having an assessable FACIT-CCSQ (<50% of missing responses) at baseline.

Patients with unknown or missing responses at week 12 followed by a nonprogressive disease response were evaluated based on response.

Patients with unknown or missing responses at week 12 or withdrawing from treatment by week 12 due to an AE were considered progressors.

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Similar(52)

In the context of longitudinal data when serial measurements are taken for each individual, MAR means that the probability of a missing response at a particular visit is related to either observed responses at previous visits or covariates, whereas CD missing - a special case of MAR - means that the probability of a missing response is dependent only upon covariates.

Ten countries were excluded because ≥90% of respondents were missing responses to at least one question of interest.

Within the THAW Survey 1760 respondents had no missing values for any of the variables to be included in the analysis (with the exception of an additional eight missing responses for where respondents walked (inside and/or outside the local area), and two missing responses for time lived at current home).

When we examined these items, it was clear that missing responses were not missing at random.

Nevertheless, overall, these figures indicate a very negligible rate of missing responses on both formats, at 0.002 % of missing values for the paper version and 0.005 % for the web-based version, and approximately 1 % for the VAS.

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