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Poor integration can manifest itself in a lack of documentation (manual pages are missing from Bioconda), missing resources or unusual on-disk locations for the included files.
Predominantly minority neighborhoods appear less attractive to white renters and buyers due to housing prices, those missing resources and the assumptions some whites continue to make about their disorder and danger, Turner said.
Although the nature of missing resources varied across place and time, there seemed consistent difficulties in access to antistaphylococcal penicillins and phenobarbitone injection, the latter being the mainstay of treatment for prolonged convulsions in children and the only therapy routinely recommended for neonatal convulsions in Kenya.
Table 2 provides an overview of available and missing resources and their relation to our method.
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As for clinical outcomes, missing resource use and QALY data will be estimated by multiple imputation.
Any missing resource item values will be replaced with imputed values and re-analysed as part of the sensitivity analysis.
Of the 130 participants who were randomised, 37 were excluded from the economic analysis due to missing resource-use or EQ-5D data.
For the returned 12-month questionnaires, a small number of missing resource use values (<3%) were imputed using mean substitution based on the observed data for the respective resource category.
Mean substitution techniques (for individual-item missing resource use data) and multiple imputation techniques (resource use data) will be carried out to ensure that all trial participants are included in the final analysis.
Additional file 1: This file provides supplementary information on the costing methods used in the study and on the techniques used to handle missing resource use data [ 17, 18, 29, 30 ]. (DOCX 30 kb).
The Stata Multivariate Imputation using Chained Equations (MICE) procedure was used to estimate missing resource use and EQ-5D observations based on patients' age, gender, baseline RMDQ score and treatment group.
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