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Typically, there are missing residues, often loops and other less-structured elements, that must be modeled in.
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The second barrier in large-scale usage of PDB data is that many PDB files have issues due to inconsistency of data and standards as well as missing residues, so that automated retrieval and analysis are often difficult.
For example, chain break, missing residues, re-numbering of residues and missing ATOM records, often hinder one-to-one mapping of information from the literature to the protein structures.
The eight missing residues that form the mediator loop are shown schematically in brown text.
The missing residues were modeled using MODELLER [65].
Both 2QQS and 2GFA structures have missing residues.
The missing residues were fixed manually.
Very often the coordinates of some of the amino acid residues of protein chain/s are not reported in the PDB entries (missing residues) either due to highly flexible nature of corresponding segments of the polypeptide and/or low resolution of the electron density maps.
Missing residues are linked by dotted lines.
Conservation of cysteine residues often implies biological significance.
Missing residues belong to three continuous gaps.
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